科研之友
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摘要
Adipogenesis is known to be controlled by the concerted actions of transcription factors and co-regulators. However, little is known about the mechanism of regulation of the transcription factors that control adipogenesis. In addition, the adipogenic roles of translational factors remain unclear. Here, we show that aminoacyl tRNA synthetase-interacting multifunctional protein 1 (AIMP1, also known as p43), an auxiliary factor that is associated with a macromolecular tRNA synthetase complex, negatively regulates adipogenesis through a direct interaction with the DNA-binding domain of peroxisome proliferator-activated receptor gamma (PPAR gamma). We found that AIMP1 expression increases during adipocyte differentiation. Adipogenesis is augmented in AIMP1-deficient cells, as compared with control cells. AIMP1 exhibits high affinity for active PPAR gamma and interacts with the DNA-binding domain of PPAR gamma, thereby inhibiting its transcriptional activity. Thus, AIMP1 appears to function as a novel inhibitor of PPAR gamma that regulates adipocyte differentiation by preventing the transcriptional activation of PPAR gamma.
- 出版日期2014-10-15
