科研之友
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摘要
Objectives To develop and validate a quantitative and observer- independent method to evaluate pial collateral circulation by DSC- perfusion MRI and test whether this novel method delivers diagnostic information which is redundant to or independent from conventional penumbra imaging by the mismatch approach. Methods We retrospectively identified 47 patients with M1 occlusion who underwent MR diffusion/perfusion imaging and mechanical thrombectomy at our facility. By automated registration and segmentation, Tmax delays were attributed specifically to the pial, cortical and parenchymal compartments. The resulting pial volumes at delay were defined as the pial Tmax map- assessed collateral score (TMACS) and correlated with gold standard digital subtraction angiography (DSA). Mismatch ratio was assessed by conventional penumbra defining MRI criteria. Results Strong correlation was found between TMACS and angiographically assessed collateral score (Pearson. = -0.74, p < 0.001). In multiple logistic regression, both good collaterals according to TMACS [OR 4.3 (1.1- 19, p = 0.04)] and mismatch ratio= 3.5 [OR 12.3 (1.88- 249, p = 0.03)] were independent predictors of favourable clinical outcome. Conclusions Perfusion delay in the pial compartment, as evaluated by TMACS, closely reflects the extent of pial collaterals in gold- standard DSA. TMACS and mismatch ratio were found to be complementary predictors of a favourable clinical outcome, each adding independent predictive information. aEuro cent MRI-DSC perfusion delay specific in the pial compartment reflects leptomeningeal collateralization. aEuro cent A novel quantitative- and observer-independent marker of collateral status (TMACS) is introduced. aEuro cent Quantification of collateral status leads to an independent predictor of neurological outcome.
- 出版日期2017-2
