Anticancer drugs loading into and in vitro release from faujasite

作者：Betsiou M; Bantsis G; Zoi I; Sikalidis C^*

来源：Clay Minerals, 2011, 46(4): 613-619.

DOI：10.1180/claymin.2011.046.4.613

• biomaterial
• drug carrier
• anticancer drugs
• adsorption and release kinetics
• molecular electrostatic potential
• faujasite
• zeolite

This investigation was carried out to determine whether the adsorptive and ion-exchange properties of faujasite (FAU) could be used to delivery locally the anticancer drugs gemcitanine hydrochloride (dFdU.HCl) and oxaliplatin (DACH-Pt). A soaking procedure was used for the determination of the maximum adsorption capacity of FAU and the mechanism described here was achieved. 274 mg dFdU. HCl/g FAU were adsorbed in 16 h, while 48 h were needed for the adsorption of 79.7 mg DACH-Pt/g FAU. Drug release studies were carried out by soaking the samples of loaded FAU in simulation body fluids (SBF). After only one hour 76% of dFdU. HCl was released while the release of DACH-Pt from the FAU was more normal since 38% of DACH-Pt was released in the first 24 h.

• 出版日期2011-12