PMEPA1, a TGF-beta- and hypoxia-inducible gene that participates in hypoxic gene expression networks in solid tumors

作者：Koido Masaru; Sakurai Junko; Tsukahara Satomi; Tani Yuri; Tomida Akihiro^*

来源：Biochemical and Biophysical Research Communications, 2016, 479(4): 615-621.

DOI：10.1016/j.bbrc.2016.09.166

• PMEPA1
• Hypoxia
• TGF-beta

Prostate transmembrane protein, androgen induced 1 (PMEPA1) is highly expressed in various solid tumors and is known to play important roles in the transforming growth factor-beta (TGF-beta) signaling pathway. Here, we demonstrate a novel relationship between PMEPA1 and hypoxia, a common micro environmental stress condition in solid tumors. We showed that induction of PMEPA1 expression occurred during hypoxia in a manner dependent on both TGF-beta signaling and hypoxia-inducible factor-1 (HIF-1) pathways. Furthermore, overexpression and knockdown experiments revealed that PMEPA1 enhanced HIF-1 transcription activity. Bioinformatics analyses of PMEPA1-correlated genes using a gene expression database in clinical settings showed significant enrichment of gene sets defined by TGF-beta and hypoxia and these two signaling pathways-related angiogenesis and epithelial-mesenchymal transition in many types of solid tumors. Collectively, our findings indicated that PMEPA1 participates in TGF-beta- and hypoxia regulated gene expression networks in solid tumors and thereby may contribute to tumor progression.

• 出版日期2016-10-28