A Regioselective Synthesis of E-Guggulsterone

作者：Ham Jungyeob; Chin Jungwook^*; Kang Heonjoong

来源：Molecules, 2011, 16(5): 4165-4171.

DOI：10.3390/molecules16054165

• guggulsterone
• inflammatory bowel diseases
• regioselective synthesis
• oppenhauer oxidation

We have successfully prepared E-guggulsterone from 16,17-epoxypregnenolone in 84% yield over two steps via a hydrazine reduction and Oppenhauer oxidation. Additionally, isomerization was induced by heat, light (h nu) and acid catalysis to convert E-guggulsterone into the corresponding Z isomer.

• 出版日期2011-5