A new EEG biomarker of neurobehavioural impairment and sleepiness in sleep apnea patients and controls during extended wakefulness

作者：D' Rozario Angela L; Kim Jong Won; Wong Keith K H; Bartlett Delwyn J; Marshall Nathaniel S; Dijk Derk Jan; Robinson Peter A; Grunstein Ronald R

来源：Clinical Neurophysiology, 2013, 124(8): 1605-1614.

DOI：10.1016/j.clinph.2013.02.022

• Obstructive sleep apnea
• Quantitative EEG
• Neurobehavioural function
• Detrended fluctuation analysis
• Power spectral analysis
• Sleep deprivation

Objective: To explore the use of detrended fluctuation analysis (DFA) scaling exponent of the awake electroencephalogram (EEG) as a new alternative biomarker of neurobehavioural impairment and sleepiness in obstructive sleep apnea (OSA). %26lt;br%26gt;Methods: Eight patients with moderate-severe OSA and nine non-OSA controls underwent a 40-h extended wakefulness challenge with resting awake EEG, neurobehavioural performance (driving simulator and psychomotor vigilance task) and subjective sleepiness recorded every 2-h. The DFA scaling exponent and power spectra of the EEG were calculated at each time point and their correlation with sleepiness and performance were quantified. %26lt;br%26gt;Results: DFA scaling exponent and power spectra biomarkers significantly correlated with simultaneously tested performance and self-rated sleepiness across the testing period in OSA patients and controls. Baseline (8am) DFA scaling exponent but not power spectra were markers of impaired simulated driving after 24-h extended wakefulness in OSA (r = 0.738, p = 0.037). OSA patients had a higher scaling exponent and delta power during wakefulness than controls. %26lt;br%26gt;Conclusions: The DFA scaling exponent of the awake EEG performed as well as conventional power spectra as a marker of impaired performance and sleepiness resulting from sleep loss. %26lt;br%26gt;Significance: DFA may potentially identify patients at risk of neurobehavioural impairment and assess treatment effectiveness.

• 出版日期2013-8
• 单位河北医科大学