Involvement of Akt/GSK3 beta/CREB signaling pathway on chronic omethoate induced depressive-like behavior and improvement effects of combined lithium chloride and astaxanthin treatment

作者：Qiao, Jingwen; Rong, Lixia; Wang, Zhaoyue; Zhang, Meizeng^*

来源：Neuroscience Letters, 2017, 649: 55-61.

DOI：10.1016/j.neulet.2017.03.048

• Lithium chloride
• Astaxanthin
• Chronic
• Omethoate
• Depressive-like behavior
• Akt/GSK3 beta/CREB signaling pathway

Chronic organophosphorus pesticides (OP) exposure is associated with an increased risk of depression, and there is an urgent need to find an effective treatment for the depressive-like symptoms caused by OP. The main purpose of this study was to investigate whether combined lithium chloride (LiCI) and astaxanthin (AST) treatment would manifest synergetic antidepressant effects on mice with chronic OP exposure, and to determine the role of the AktiGSK3 beta/CREB signaling pathway. Our results showed that chronic omethoate exposure significantly increased immobility time in behavioral tests and induced neuron damage in HE staining. The expression of p-GSK3 beta, p-CREB, p-PI3K and p-Akt in hippocampus after OP exposure were significantly down-regulated, while the influences were reversed by LiCI and AST treatment. Moreover, the combined application of AST and LiCI had synergistic therapeutic effects compared to LiCI and AST treatment alone, the expression of p-GSK3 beta, p-CREB, p-PI3K and p-Akt after combined LiCl-AST treatment were significantly higher than that with single drug application. These results showed that the combination of LiCl and AST could efficiently ameliorate depressive-like behavior induced by omethoate, and AktiGSK3 beta/CREB signaling pathway might be responsible for the neuroprotective effect.

• 出版日期2017-5-10
• 单位青岛大学