Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

Watanabe Yoshihiro; Suga Takuya; Narusawa Satomi; Iwatsuki Masato; Nonaka Kenichi; Nakashima Takuji; Shinohara Yasuo; Shiotsuki Takahiro; Ichimaru Naoya; Miyoshi Hideto; Asami Yukihiro; Omura Satoshi; Shiomi Kazuro

doi:10.1038/ja.2016.164

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Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae

作者：Watanabe Yoshihiro; Suga Takuya; Narusawa Satomi; Iwatsuki Masato; Nonaka Kenichi; Nakashima Takuji; Shinohara Yasuo; Shiotsuki Takahiro; Ichimaru Naoya; Miyoshi Hideto; Asami Yukihiro; Omura Satoshi; Shiomi Kazuro

来源：Journal of Antibiotics, 2017, 70(4): 395-399.

DOI：10.1038/ja.2016.164

摘要

A new decalin, decatamariic acid, was isolated from a cultured broth of the fungus Aspergillus tamarii FKI-6817. Its absolute configuration was elucidated by NMR and electronic circular dichroism. Decatamariic acid (10 mu m) elicited similar to 50% inhibition of the ATP production in mitochondria isolated from wild-type Saccharomyces cerevisiae without affecting the activities of respiratory enzymes. The action manner of this compound may be interesting as a possible seed for new pesticides.