Association of Chlamydia pneumoniae immunoglobulin G antibodies with the risk of lung cancer among non-smoking women in Liaoning, China

作者：Liu, Zhuang; Su, Meng; Yu, Shi-cheng; Yin, Zhi-hua; Zhou, Bao-sen^*

来源：Thoracic Cancer, 2010, 1(3): 126-129.

DOI：10.1111/j.1759-7714.2010.00021.x

• Chlamydia pneumoniae IgG antibodies
• immunoglobulin
• lung cancer

The role of Chlamydia pneumoniae in the cause of lung cancer is controversial. In this study, we investigated the association between C. pneumoniae immunoglobulin (Ig) G antibodies and risk of lung cancer among non-smoking women. C. pneumoniae IgG antibody levels were compared between 192 adult Chinese women who met the diagnostic criteria of lung cancer and 90 healthy controls. C. pneumoniae IgG antibodies were tested with the use of an enzyme-linked immunosorbent assay. The prevalence of C. pneumoniae IgG seropositivity was 61.98% of cases and 28.89% of controls (P < 0.05). According to the results of the multiple logistic analysis model, the odds ratios for C. pneumoniae IgG antibody seropositivity, body mass index, and educational levels were 3.919 (P < 0.001), 0.731 (P = 0.274), and 1.646 (P = 0.069), respectively. C. pneumoniae infection may be a risk factor for lung cancer.

• 出版日期2010-9
• 单位中国疾病预防控制中心; 中国医科大学; 辽宁大学; 辽宁省肿瘤医院