Uncommon Trimethoxylated Flavonol Obtained from Rubus rosaefolius Leaves and Its Antiproliferative Activity

作者：Petreanu Marcel; Ferreira Emili Kamila; Sagaz Ana Paula M; Vendramini Costa Debora B; Ruiz Ana Lucia T G; De Carvalho Joao Ernesto; Campos Adriana; Cechinel Filho Valdir; Delle Monache Franco; Niero Rivaldo^*

来源：Evidence-Based Complementary and Alternative Medicine, 2015, 2015: 341216.

DOI：10.1155/2015/341216

This study shows the evaluation the antiproliferative effect of the extract, fractions, and uncommon compounds isolated from R. rosaefolius leaves. The compounds were identified by conventional spectroscopic methods such as NMR-H-1 and C-13 and identified as 5,7-dihydroxy-6,8,4'-trimethoxyflavonol (1), 5-hydroxy-3,6,7,8,4'-pentamethoxyflavone (2), and tormentic acid (3). Both hexane and dichloromethane fractions showed selectivity formultidrug-resistant ovary cancer cell line (NCI-ADR/RES) with total growth inhibition values of 11.1 and 12.6 mu g/ml, respectively. Compound 1 also showed selective activity against the same cell line (18.8 mu g/ml); however, it was especially effective against glioma cells (2.8 mu g/ml), suggesting that this compound may be involved with the in vitro antiproliferative action.

• 出版日期2015