科研之友
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摘要
A novel platinum complex, named as saliplatin, was designed, synthesized and characterized with element analysis, coupled inductively plasma-mass spectrum, gravitational thermal-differential thermal analysis, ultraviolet-visible absorption spectrum, infrared spectrum, fast atom bombment mass spectrum and H-1 NMR, etc. Its purity was investigated and determined. HPLC-ESI-MS was employed to separate the platinum complex and the impurity, and to identify and quantify the latter. It proved that the impurity in,this novel compound was 3,5-diisopropylsalic acid, a reactant used in the synthesis of the novel platinum complex, identified with ESI-MS. The mass fraction was determined with HPLC as 4.3%, which meant that the purity of this new substance was 95.7%.
