A Straightforward Approach to Tetrahydroindolo[3,2-b]carbazoles and 1-Indolyltetrahydrocarbazoles through [3+3] Cyclodimerization of Indole-Derived Cyclopropanes

作者：Ivanova Olga A; Budynina Ekaterina M; Khrustalev Victor N; Skvortsov Dmitriy A; Trushkov Igor V; Melnikov Mikhail Ya

来源：Chemistry - A European Journal, 2016, 22(4): 1223-1227.

DOI：10.1002/chem.201502287

<jats:title>Abstract</jats:title><jats:p>A rapid new approach to produce biologically relevant bisindoles, namely indolyltetrahydrocarbazoles and indolo[3,2‐<jats:italic>b</jats:italic>]carbazoles, has been developed, based on the Ga(OTf)<jats:sub>3</jats:sub>‐catalyzed [3+3] cyclodimerization of indole‐derived donor–acceptor cyclopropanes. Chemoselectivity of the process depends on the location of the three‐membered ring at the indole core.</jats:p>

• 出版日期2016-1-22