Antioxidants and biomarkers of oxidative damage in the saliva of patients with Down's syndrome

作者：de Sousa Michelle Cardoso; Vieira Rafael Brizola; dos Santos Danielle Sa; Talge Carvalho Claudio Antonio; Afonso Camargo Samira Esteves; Gasparoto Mancini Maria Nadir; de Oliveira Luciane Dias

来源：Archives of Oral Biology, 2015, 60(4): 600-605.

DOI：10.1016/j.archoralbio.2014.09.013

• Down's syndrome
• Saliva
• Oxidative stress
• Antioxidants
• Malondialdehyde

Background: The aim of this study was to investigate enzymatic and non-enzymatic antioxidant systems and levels of biomarker levels of oxidative damage in the saliva of patients with Down's syndrome (DS).
Methods: Saliva samples were collected from 30 patients with DS and control group (age: 1424 years). Subsequently, the concentrations of superoxide dismutase, concentration of malondialdehyde, carbonylated proteins, uric acid, vitamin C and total protein, peroxidase activity and total antioxidant capacity were analyzed.
Results: Patients with DS presented significantly higher concentrations of superoxide dismutase, higher levels of malondialdehyde and salivary total protein content than controls (p < 0.05). Conversely, no difference in carbonylated proteins or antioxidants (uric acid, vitamin C, peroxidase, and total antioxidant capacity) was observed between DS patients and controls (p > 0.05).
Conclusion: Patients with DS are more vulnerable to oxidative stress in saliva as indicated by the significant increase in malondialdehyde and superoxide dismutase concentrations found in this study.

• 出版日期2015-4
• 单位Univ Estadual Paulista