RASSF4: Regulator of plasma membrane PI(4,5)P-2

作者:Dickson Eamonn J*
来源:The Journal of Cell Biology, 2017, 216(7): 1878-1881.
DOI:10.1083/jcb.201706042

摘要

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P-2) is a negatively charged phospholipid that plays a major role in recruiting and regulating proteins at the plasma membrane-cytosol interface. In this issue, Chen et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201606047) demonstrate that RAS association domain family 4 (RASSF4) positively influences PI(4,5) P2 synthesis through ARF6-dependent regulation of PIP5K.

  • 出版日期2017-7