A one-pot route to thioamides discovered by gas-phase studies: palladium-mediated CO2 extrusion followed by insertion of isothiocyanates

作者：Noor Asif; Li Jiawei; Khairallah George N; Li Zhen; Ghari Hossein; Canty Allan J; Ariafard Alireza^*; Donnelly Paul S^*; O'Hair Richard A J^*

来源：Chemical communications, 2017, 53(27): 3854-3857.

DOI：10.1039/c7cc00865a

A new palladium mediated "one pot'' synthesis of thioamides from aromatic carboxylic acids (ArCO2H + RNCS -> ArC(S)NHR + CO2) was discovered by gas-phase experiments and theoretical studies. Palladium-mediated decarboxylation of aromatic carboxylic acids followed by addition of substituted isothiocyanates leads to the corresponding thioamide derivatives.

• 出版日期2017-4-7