A New Method for the Synthesis of 1,4-Diols: C(sp(3))-H Hydroxylation Induced by Iron-Catalyzed Redox Hydration of Alkenes

作者：Taniguchi Tsuyoshi^*; Hirose Daisuke; Hashimoto Takuma

来源：Synlett, 2014, 25(18): 2531-2535.

DOI：10.1055/s-0034-1379214

• alkenes
• hydroxylation
• iron
• oxygen
• radicals

A novel method for the synthesis of 1,4-diols from alkenes is presented. The reaction is the basis of iron-catalyzed redox hydration of alkenes. The second hydroxyl group is introduced by hydroxylation of an inert C-H bond. The mechanism includes a radical 1,5-hydrogen-transfer process of an intermediary alkoxy radical. In this paper, we describe how this new method has been discovered and developed.

• 出版日期2014-11
• 单位河北医科大学