Net Oxidative Addition of C(sp(3))-F Bonds to Iridium via Initial C-H Bond Activation

作者：Choi Jongwook; Wang David Y; Kundu Sabuj; Choliy Yuriy; Emge Thomas J; Krogh Jespersen Karsten^*; Goldman Alan S

来源：Science, 2011, 332(6037): 1545-1548.

DOI：10.1126/science.1200514

Carbon-fluorine bonds are the strongest known single bonds to carbon and as a consequence can prove very hard to cleave. Alhough vinyl and aryl C-F bonds can undergo oxidative addition to transition metal complexes, this reaction has appeared inoperable with aliphatic substrates. We report the addition of C(sp(3))-F bonds (including alkyl-F) to an iridium center via the initial, reversible cleavage of a C-H bond. These results suggest a distinct strategy for the development of catalysts and promoters to make and break C-F bonds, which are of strong interest in the context of both pharmaceutical and environmental chemistry.

• 出版日期2011-6-24