A strategy for strong interface bonding by 3D bioprinting of oppositely charged kappa-carrageenan and gelatin hydrogels

作者：Li Huijun; Tan Yu Jun; Li Lin^*

来源：Carbohydrate Polymers, 2018, 198: 261-269.

DOI：10.1016/j.carbpol.2018.06.081

• Bioprinting
• Hydrogel
• Interface
• Gelatin
• kappa-carrageenan

A promising approach for improving the interfacial bonding of a three-dimensionally (3D) printed multilayered structure has been investigated by taking advantage of the electrostatic interactions between two hydrogels with oppositely charges. Here, two hydrogels namely gelatin and.-carrageenan, which are the cationic and anionic hydrogels respectively, are used. It is found that the interfacial bonding strength between these two oppositely charged hydrogels is significantly higher than that of a bilayered gelatin or a bilayered kappa-carrageenan. The bioprinted multilayered kappa-carrageenan-gelatin hydrogel construct demonstrates a very good biocompatibility and a good structure integrity at 37 degrees C. Our strategy also overcomes the limitation of using gelatin for biofabrication at 37 degrees C, without further post crosslinking.

• 出版日期2018-10-15
• 单位南阳理工学院