A convenient access to alpha(V)beta(3)/alpha(V)beta(5) integrin ligand conjugates: regioselective solid-phase functionalisation of an RGD based peptide

作者：Boturyn D; Dumy P^*

来源：Tetrahedron Letters, 2001, 42(15): 2787-2790.

DOI：10.1016/S0040-4039(01)00293-3

The cyclopeptide (-RGDfK-) is a potent and selective alpha (V)beta (3)/alpha (V)beta (5) integrin ligand. A methodology for the conjugation of cyclo(-RGDfK-) through the regioselective derivatisation of lysine side chains, either in solution or directly on the solid support, is described. This provides a rapid and flexible chemical entry to conjugated integrin ligands bearing reporter groups for biological investigations or reactive chemical functions for the preparation of new vector systems.

• 出版日期2001-4-9