Maternal obesity and risk of cerebral palsy in children: a systematic review and meta-analysis

作者：Zhang, Jian^*; Peng, Linrui; Chang, Qingxian; Xu, Ruoting; Zhong, Nanbert; Huang, Qitao^*; Zhong, Mei; Yu, Yanhong

来源：Developmental Medicine and Child Neurology, 2019, 61(1): 31-+.

DOI：10.1111/dmcn.13982

• GESTATIONAL WEIGHT-GAIN
• BODY-MASS INDEX
• PREPREGNANCY OBESITY
• EARLY-PREGNANCY
• ASSOCIATION
• INFLAMMATION
• BIRTH
• INHERITANCE
• POPULATION
• PREVALENCE

AimSeveral studies have examined the links between maternal obesity and the risk of cerebral palsy (CP) in children, with inconsistent results. The aim of our study was to investigate whether maternal obesity is associated with increased risk of CP in offspring by using meta-analysis. @@@ MethodPubMed and Web of Science were searched until August 2017. Observational studies relevant to the maternal obesity and risk of CP in children were extracted and compiled. Meta-analyses were performed for different obesity levels and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were reported. @@@ ResultsA total of five cohort studies involving 12324 cases and 7919288 participants were included in our meta-analysis. The pooled crude and adjusted ORs (95% CIs) were 1.65 (1.38-1.98) and 1.51 (1.24-1.84) respectively. Additionally, the pooled OR (95% CI) for CP in offspring in relation to maternal obesity class I (body mass index [BMI] 30.0-34.9), class II (BMI 35.0-39.9), and class III (BMI40.0) compared with normal weight during prepregnancy or pregnancy was 1.31 (1.15-1.50), 1.65 (1.34-2.02), and 2.37 (1.91-2.94) respectively. @@@ InterpretationThis meta-analysis demonstrated that increasing grades of maternal obesity are associated with a higher risk of CP in offspring.

• 出版日期2019-1
• 单位南方医科大学