Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women

作者：Mackelprang R D; Scoville C W; Cohen C R; Ondondo R O; Bigham A W; Celum C; Campbell M S; Essex M; Wald A; Kiarie J; Ronald A; Gray G; Lingappa J R^*

来源：Genes and Immunity, 2015, 16(5): 362-365.

DOI：10.1038/gene.2015.13

Bacterial vaginosis (BV) is a common vaginal syndrome associated with altered microflora that increases the risk of preterm delivery and acquisition of sexually transmitted diseases. The cause of BV is unknown although toll-like receptors (TLRs), that are central to innate immune responses, may be important. We evaluated associations between TLR SNPs and BV among HIV-1 infected and uninfected African women. Logistic regression was used to assess associations between SNPs (N = 99) in TLRs 2-4, 7-9 and BV (as classified by Nugent's criteria). Among HIV-1 uninfected women, TLR7 rs5743737 and TLR7 rs1634323 were associated with a decreased risk of BV, whereas TLR7 rs179012 was associated with an increased risk. TLR2 SNP rs3804099 was associated with a decreased risk of BV among HIV-1 infected women. Our findings indicate that there may be differences in TLR association with BV among HIV-1 infected and HIV-1 uninfected women.

• 出版日期2015-8