Distribution and chemical coding patterns of cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) neurons in the enteric nervous system of the porcine stomach cardia

作者：Rekawek W; Sobiech P^*; Gonkowski S; Zarczynska K; Snarska A; Wasniewski T; Wojtkiewicz J

来源：Polish Journal of Veterinary Sciences, 2015, 18(3): 515-522.

DOI：10.1515/pjvs-2015-0067

• Cocaine- and amphetamine-regulated transcript (CART)
• enteric nervous system (ENS)
• stomach
• immunohistochemistry
• pig

The aim of this study was to determine the presence of cocaine- and amphetamine-regulated transcript-like immunoreactive (CART-LI) neurons and co-localisation of CART with vesicular acetylcholine transporter (VAChT), neuronal nitric oxide synthase (n-NOS), vasoactive intestinal polypeptide (VIP), substance P (SP) and leu-enkephalin (LENK) in the enteric nervous system of the porcine gastric cardia by using a double-labelling immunofluorescence technique. CART-LI neurons were observed in the myenteric plexus (18.2 +/- 2.6%). A dense network of CART-LI nerve fibers was mainly observed in the muscular layer. CART showed co-localization mainly with VAChT, n-NOS, VIP and to a lesser degree with LENK and SP. Distribution of CART and its co-localization with other neurotransmitters suggest that this peptide plays an important role in gastric motility in the pig.

• 出版日期2015