Acute Effect of Aloe vera Gel Extract on Experimental Models of Pain

作者：Rathor Naveen; Mehta Ashish K; Sharma Amit K; Mediratta Pramod K^*; Sharma Krishna K

来源：Inflammation, 2012, 35(6): 1900-1903.

DOI：10.1007/s10753-012-9512-z

• Aloe vera
• tail-flick test
• formalin test
• inflammatory pain

The present study was performed to explore the effect of aqueous extract of Aloe vera on behavioural parameters of pain. Pain assessment was performed by the tail-flick and formalin tests. A. vera (100 mg/kg, per oral (p.o.)) produced an insignificant decrease in the pain response in the tail-flick and formalin tests. Moreover, A. vera (200 and 400 mg/kg, p.o.) did not have significant effect on the tail-flick test. However, A. vera (200 and 400 mg/kg, p.o.) significantly decreased the second phase of the formalin-induced pain. Thus, these findings suggest that A. vera exerts its effect by a peripheral mechanism of action rather than central.

• 出版日期2012-12