Actions of melatonin mixed with collagenized porcine bone versus porcine bone only on osteointegration of dental implants

作者：Luis Calvo Guirado Jose; Gomez Moreno Gerardo; Lopez Mari Laura; Guardia Javier; Maria Marinez Gonzalez Jose; Barone Antonio; Tresguerres Isabel F; Paredes Sergio D; Fuentes Breto Lorena

来源：Journal of Pineal Research, 2010, 48(3): 194-203.

DOI：10.1111/j.1600-079X.2009.00743.x

• Beagle dogs
• dental implants
• melatonin
• osteointegration

This study evaluated the effect of the topical application of melatonin mixed with collagenized porcine bone on the osteointegration on the rough discrete calcium deposit (DCD) surface implants in Beagle dogs 3 months after their insertion. In preparation for subsequent insertion of dental implants, lower molars were extracted from 12 Beagle dogs. Each mandible received two parallel wall expanded platform implants with a DCD surface of 4 mm in diameter and 10 mm in length. The implants were randomly assigned to the distal sites on each mandible in the molar area and the gaps were filled with 5 mg lyophilized powdered melatonin and porcine bone and collagenized porcine bone alone. Ten histological sections per implant were obtained for histomorphometric studies. After a 4-wk treatment period, melatonin plus porcine bone significantly increased the perimeter of bone that was in direct contact with the treated implants (P < 0.0001), bone density (P < 0.0001), and new bone formation (P < 0.0001) in comparison with porcine bone alone around the implants. Melatonin plus collagenized porcine bone on DCD surface may act as a biomimetic agent in the placement of endo-osseous dental implants and enhance the osteointegration. Melatonin combined with porcine bone on DCD implants reveals more bone in implant contact at 12 wk (84.5 +/- 1.5%) compared with porcine bone alone treated area (67.17 +/- 1.2%).

• 出版日期2010-4