A fragment based click chemistry approach towards hybrid G-quadruplex ligands: design, synthesis and biophysical evaluation

作者：Ritson Dougal J; Moses John E^*

来源：Tetrahedron, 2012, 68(1): 197-203.

DOI：10.1016/j.tet.2011.10.066

• Click chemistry
• G-quadruplex
• Telomerase inhibitor
• Cancer
• Telomestatin

A library of hybrid oxazole-triazole based compounds containing contiguously linked aromatic units were synthesised as G-quadruplex binding ligands. The design of these ligands was based upon combining features of our first generation of G-quadruplex bis-triazole ligands and the natural product telomestatin. The syntheses and biophysical studies of these ligands are described.

• 出版日期2012-1-7