Nanofibers Self-assembled from Structural Complementary Borono-decapeptides

作者：Chen, Chang-Sheng; Ji, Tian-Jiao; Xu, Xiao-Ding; Zhang, Xian-Zheng^*; Zhuo, Ren-Xi

来源：Macromolecular Rapid Communications, 2010, 31(21): 1903-1908.

DOI：10.1002/marc.201000292

• nanofibers
• peptide
• structural complementary
• self-assembly

A series of structural complementary decapeptides with phenyl boronic acid tails or borono-decapeptides (BPs) were designed and synthesized for supramolecular self-assembly. After dissolving these borono-decapeptides in deionized (DI) water, well-defined nanofibers were formed in BP1 (B(OH)(2)VEKELVKEKL-OH) and BP3 (B(OH)(2)AELELARARL-OH). It was found that the self-assembled borono-decapeptide BP1 and BP3 have a parallel beta-sheet conformation in the formed nanofibers. The strategy demonstrated here shows a great prospect in preparation of well-ordered nanofibers via rationally designing the molecular structures of peptides.

• 出版日期2010-11-1
• 单位武汉大学