Angiosarcoma in HIV-negative patients is not associated with HHV-8

作者：Avancini Joao^*; Zanata Cherubim Andre Pires; de Oliveira Cristina Mendes; Sakai Valente Neusa Yuriko; Festa Neto Cyro; Sanches Jose Antonio; Pazzini Renato; Sumita Laura Masami; Pannuti Claudio Sergio

来源：Anais Brasileiros de Dermatologia, 2016, 91(6): 738-741.

DOI：10.1590/abd1806-4841.20164730

• Hemangiosarcoma
• Herpesvirus 8
• human
• HIV

BACKGROUND: Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined.
OBJECTIVE: To investigate the relationship between the presence of HHV-8 and angiosarcoma.
METHODS: In this study, the team investigated the relationship between the presence of HHV-8, as determined by polymerase chain reaction, and angiosarcoma, using samples from patients with epidemic Kaposi's sarcoma as controls.
RESULTS: While all control cases with epidemic Kaposi's sarcoma were positive for HHV-8, none of the angiosarcoma cases was.
CONCLUSION: These findings support most previous studies that found no association between HHV-8 and angiosarcoma.

• 出版日期2016-12