Determination of the lipophilicity of potential antituberculotic compounds by RP-TLC

作者：Mrkvickova Zlata^*; Kovarikova Petra; Klimes Jiri; Dolezal Martin

来源：JPC-Journal of Planar Chromatography-Modern TLC, 2006, 19(112): 422-426.

DOI：10.1556/JPC.19.2006.6.3

• lipophilicity
• RP-TLC
• log P
• antituberculotics

RP-TLC retention behavior has been studied for a series of potential antituberculotic drugs from a group of substituted anilides of pyrazine-2-carboxylic acid. Lipophilicity was determined by use of reversed-phase thin-layer chromatography with methanol-water mobile phases. R(MW) values were obtained by extrapolation of R(MW) (determined by RP-TLC) to methanol-free conditions. These experimental lipophilicity values were correlated with lipophilicity (log P) calculated by use of three software products. Good correlation was obtained between R(MW) and log P. The results of this study could be used in further experiments focused on investigation of the biological activity of these newly prepared compounds and other potential antituberculotic drugs with closely similar chemical structures.

• 出版日期2006-12