Analysis of long-term monomer elution from bulk-fill and conventional resin-composites using high performance liquid chromatography

作者：Alshali Ruwaida Z; Salim Nesreen A; Sung Rehana; Satterthwaite Julian D; Silikas Nick^*

来源：Dental Materials, 2015, 31(12): 1587-1598.

DOI：10.1016/j.dental.2015.10.006

• Monomer
• Liquid chromatography
• Mass spectrometry
• Bulk-fill
• Resin-composites

Objective. The aim of this study was to assess monomer elution from bulk-fill and conventional resin-composites stored in different media using high performance liquid chromatography (HPLC) for up to 3 months.
Methods. Six bulk-fill (SureFil SDR, Venus Bulk Fill, X-tra base, Filtek Bulk Fill flowable, Sonic Fill, and Tetric EvoCeram Bulk Fill) and eight conventional resin-composites (Grandioso Flow, Venus Diamond Flow, X-Flow, Filtek Supreme XTE, Grandioso, Venus Diamond, TPH Spectrum, and Filtek Z250) were tested. Cylindrical samples (n = 5) were immersed in water, 70% ethanol/water solution (70% E/W), and artificial saliva and stored at 37 degrees C for 24 h, 1 month, and 3 months. The storage solutions were analysed with HPLC. Data were analysed with repeated measures ANOVA, one-way ANOVA, and Tukey post hoc test at alpha = 0.05.
Results. Monomers detected in water and artificial saliva were TEGDMA, DEGDMA, UDMA, and TCD-DI-HEA. No eluted monomers were detected from X-tra base and Sonic fill in these media. All monomers showed a variable extent of elution into 70% E/W with significantly higher amounts than those detected in water and artificial saliva. Significantly higher elution was detected from UDMA-BisEMA based composites compared to BisGMA and BisGMA-BisEMA based systems in 70% E/W. The rate of elution into different media varied between different monomers and was highly dependent on the molecular weight of the eluted compounds.
Significance. Elution from bulk-fill resin-composites is comparable to that of conventional materials despite their increased increment thickness. Monomer elution is highly dependent on the hydrophobicity of the base monomers and the final network characteristics of the resin-matrix.

• 出版日期2015-12