Nanoparticle-dendrimer hybrid nanocapsules for therapeutic delivery

作者：Jeong Youngdo; Kim Sung Tae; Jiang Ying; Duncan Bradley; Kim Chang Soo; Saha Krishnendu; Yeh Yi Cheun; Yan Bo; Tang Rui; Hou Singyuk; Kim Chaekyu; Park Myoung Hwan; Rotello Vincent M^*

来源：Nanomedicine, 2016, 11(12): 1571-1578.

DOI：10.2217/nnm-2016-0034

• cancer therapy
• drug delivery
• nanocapsule
• paclitaxel
• sustained drug release

Background: Nanocapsules can efficiently encapsulate therapeutic cargo for anticancer drug delivery. However, the controlled release of the payload remains a challenge for effective drug delivery. Materials & methods: We used dithiocarbamate-functionalized PAMAM dendrimer to cross-link the shell of arginine gold nanoparticles stabilized nanocapsule, and controlled the drug release from the nanocapsule. The ability of cross-linked nanocapsule to deliver hydrophobic paclitaxel to B16F10 cells was demonstrated both in vitro and in vivo. Results: Cross-linked nanocapsule possesses tunable stability and modular permeability, and can deliver paclitaxel with improved anticancer efficiency compared with free drug both in vitro and in vivo. Conclusion: Dithiocarbamate chemistry provides a new tool to harness multifactorial colloidal self-assembly for controlled drug delivery for cancer therapy.

• 出版日期2016-6