A deno-associated virus finds its disease

Russell David W<sup>*</sup>; Grompe Markus

doi:10.1038/ng.3407

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A deno-associated virus finds its disease

作者：Russell David W^*; Grompe Markus

来源：Nature Genetics, 2015, 47(10): 1104-1105.

DOI：10.1038/ng.3407

摘要

Adeno-associated virus (AAV) vectors have been widely adopted for use in gene therapy. A new study raises concerns regarding this approach, reporting that chromosomal insertions of AAV serotype 2 seem to activate proto-oncogenes in human hepatocellular carcinoma.