A New Sesquiterpenoid Derivative from the Coastal Saline Soil Fungus Aspergillus fumigatus

作者：Liu, Desheng; Huang, Yuling; Li, Chunmin; Ma, Liying; Pan, Xiaohong; Ferreira, Daneel; Liu, Weizhong^*

来源：Records of Natural Products, 2016, 10(6): 708-713.

• secondary metabolites
• Aspergillus fumigatus
• cytotoxic activity
• coastal saline soil

A new sesquiterpenoid derivative, named aspergiketone (1), along with seven known compounds (2-8) were isolated from the coastal saline soil fungus Aspergillus fumigatus. Their structures were elucidated by spectroscopic analysis, and by comparison of experimental and reported data. The absolute configuration of compound 1 was defined by X-ray diffraction analysis. Compound 1 was cytotoxic towards HL-60 and A549 cell lines with IC50 values of 12.4 and 22.1 mu M, respectively.

• 出版日期2016
• 单位济南市妇幼保健院; 滨州医学院