Agency for Healthcare Research and Quality Evidence-based Practice Center methods provide guidance on prioritization and selection of harms in systematic reviews

作者：Chou Roger^*; Baker William L; Banez Lionel L; Iyer Suchitra; Myers Evan R; Newberry Sydne; Pincock Laura; Robinson Karen A; Sardenga Lyndzie; Sathe Nila; Springs Stacey; Wilt Timothy J

来源：Journal of Clinical Epidemiology, 2018, 98: 98-104.

DOI：10.1016/j.jclinepi.2018.01.007

• Harms
• Systematic reviews
• Comparative effectiveness review
• Study methodology
• Recommendations
• Adverse effects

Objectives: Systematic reviews should provide balanced assessments of benefits and harms, while focusing on the most important outcomes. Selection of harms to be reviewed can be a challenge due to the potential for large numbers of diverse harms.
Study Design and Setting: A workgroup of methodologists from Evidence-based Practice Centers (EPCs) developed consensus-based guidance on selection and prioritization of harms in systematic reviews. Recommendations were informed by a literature scan, review of Evidence-based Practice Center reports, and interviews with experts in conducting reviews or assessing harms and persons representing organizations that commission or use systematic reviews.
Results: Ten recommendations were developed on selection and prioritization of harms, including routinely focusing on serious as well as less serious but frequent or bothersome harms; routinely engaging stakeholders and using literature searches and other data sources to identify important harms; using a prioritization process (formal or less formal) to inform selection decisions; and describing the methods used to select and prioritize harms.
Conclusion: We provide preliminary guidance for a more structured approach to selection and prioritization of harms in systematic reviews.

• 出版日期2018-6