Nanomechanical characterization of red blood cells using optical tweezers

作者：Li Chuan; Liu K K^*

来源：Journal of Materials Science: Materials in Medicine , 2008, 19(4): 1529-1535.

DOI：10.1007/s10856-008-3382-9

Deformation behaviours of red blood cells (RBCs) have been studied by applying stretching forces via optical tweezers. Combined with finite-element analyses (FEA), the RBCs' mechanical properties are determined quantitatively based on a best fitting between the experimental deformed geometries and the simulated counterparts. Experimentally, a silica beads attached erythrocyte is optical-mechanically stretched to different lengths. On the theoretical front, a large deformation model with Mooney-Rivlin constitutive equations has been simulated by using FEA to predict the cell deformation geometries. The numerically simulated transverse and longitudinal strains which are in a good agreement with the experimental measurements facilitate the determination of elastic constants of the cells.

• 出版日期2008-4
• 单位南阳理工学院