Organocatalytic asymmetric nitrocyclopropanation of alpha,beta-unsaturated aldehydes

作者：Vesely Jan; Zhao Gui Ling; Bartoszewicz Agnieszka; Cordova Armando^*

来源：Tetrahedron Letters, 2008, 49(27): 4209-4212.

DOI：10.1016/j.tetlet.2008.04.162

A novel organocatalytic highly enantioselective nitrocyclopropanation reaction of alpha,beta-unsaturated aldehydes is presented. The 1-nitro-2-formylcyclopropane derivatives synthesized from this catalytic transformation were converted to the corresponding beta-nitromethyl-acid esters, which are excellent precursors of GABA analogues such as Baclofen, by subsequent organocatalytic chemoselective ring-opening.

• 出版日期2008-6-30