A New Approach to the Synthesis of Functional Derivatives of 3-(4-Pyridinyl)-1H-indole and 4-(1H-Indol-3-yl)thieno[2,3-b]pyridine

作者：Dotsenko V V^*; Krivokolysko S G; Krivokolysko B S; Frolov K A

来源：Russian Journal of General Chemistry, 2018, 88(4): 682-688.

DOI：10.1134/S1070363218040114

• cyanothioacetamide
• 3-(pyridine-4-yl)-1H-indoles
• 6-amino-3,5-dicyanopyridine-2-thiolate
• Thorpe-Ziegler cyclization
• thieno[2,3-b]pyridines

Sequential reaction of indole-3-carbaldehyde with cyanothioacetamide and KOH led to the formation of potassium 6-amino-4-(1H-indol-3-yl)-3,5-dicyanopyridine-2-thiolate. S-Alkylation of the latter afforded new functional derivatives of 3-(pyridine-4-yl)-1H-indole and 4-(1H-indol-3-yl)-thieno[2,3-b]pyridine.

• 出版日期2018-4