A novel synthesis of 1-aryl-3-piperidone derivatives

作者：Zhang Yinan; Silverman Richard B^*

来源：Tetrahedron Letters, 2013, 54(6): 573-575.

DOI：10.1016/j.tetlet.2012.11.085

• 3-Piperidone
• Synthesis
• Morita-Baylis-Hillman
• Ring-closing metathesis
• Heterocycles

A novel method to construct the 1-aryl-3-piperidone scaffold is described here. Starting from 3,5-dichloroaniline, a seven-step synthesis, without the use of protecting groups, generates the desired 3-piperidone ring in an overall yield of 30% through a key Morita-Baylis-Hillman reaction and ring-closing metathesis, providing an easy access to diverse and useful heterocycles.

• 出版日期2013-2-6
• 单位西北大学