Augmented pressor and sympathetic responses to skeletal muscle metaboreflex activation in type 2 diabetes patients

作者：Holwerda Seth W; Restaino Robert M; Manrique Camila; Lastra Guido; Fisher James P; Fadel Paul J

来源：American Journal of Physiology - Heart and Circulatory Physiology, 2016, 310(2): H300-H309.

DOI：10.1152/ajpheart.00636.2015

• exercise
• hypertension
• muscle sympathetic nerve activity
• postexercise ischemia
• blood pressure

Previous studies have reported exaggerated increases in arterial blood pressure during exercise in type 2 diabetes (T2D) patients. However, little is known regarding the underlying neural mechanism(s) involved. We hypothesized that T2D patients would exhibit an augmented muscle metaboreflex activation and this contributes to greater pressor and sympathetic responses during exercise. Mean arterial pressure (MAP), heart rate (HR), and muscle sympathetic nerve activity (MSNA) were measured in 16 patients with T2D (8 normotensive and 8 hypertensive) and 10 healthy controls. Graded isolation of the muscle metaboreflex was achieved by postexercise ischemia (PEI) following static handgrip performed at 30% and 40% maximal voluntary contraction (MVC). A cold pressor test (CPT) was also performed as a generalized sympathoexcitatory stimulus. Increases in MAP and MSNA during 30 and 40% MVC handgrip were augmented in T2D patients compared with controls (P < 0.05), and these differences were maintained during PEI (MAP: 30% MVC PEI: T2D, Delta 16 +/- 2 mmHg vs. controls, Delta 8 +/- 1 mmHg; 40% MVC PEI: T2D, Delta 26 +/- 3 mmHg vs. controls, Delta 16 +/- 2 mmHg, both P < 0.05). MAP and MSNA responses to handgrip and PEI were not different between normotensive and hypertensive T2D patients (P > 0.05). Interestingly, MSNA responses were also greater in T2D patients compared with controls during the CPT (P < 0.05). Collectively, these findings indicate that muscle metaboreflex activation is augmented in T2D patients and this contributes, in part, to augmented pressor and sympathetic responses to exercise in this patient group. Greater CPT responses suggest that a heightened central sympathetic reactivity may be involved.

• 出版日期2016-1-15