Antispasmodic effect of Ocimum selloi essential oil on the guinea-pig ileum

作者：Souza Sylvia D F; Franca Carolina S L; Niculau Edenilson S; Costa Larissa C B; Pinto Jose E B; Alves Pericles B; Marcal Rosilene M^*

来源：Natural Product Research, 2015, 29(22): 2125-2128.

DOI：10.1080/14786419.2014.989392

• Ocimum selloi
• spasmolytic
• methyl chavicol

Ocimum selloi is an herbal species popularly used in Brazil as antispasmodic. Herein, we report the antispasmodic effect of O. selloi essential oil (OS) in segments of guinea-pig ileum. OS did not reduce the tonus of the ileum. In contrast, OS reduced the contraction induced by carbachol (100M), BaCl2 (0.03M) and low- and high-K+ concentrations (25 and 60mM, respectively). OS shifted the concentration-response curve for calcium to the right in a parallel manner. GC/MS analysis showed that OS consists mostly of methyl chavicol (97.57%). These results suggest that OS antispasmodic effect is mediated through calcium channel blockade. In addition, OS effect and mode of action could be accounted for methyl chavicol.

• 出版日期2015-11-17