A farnesoid X receptor polymorphism predisposes to spontaneous bacterial peritonitis

作者：Lutz Philipp^*; Berger Cordula; Langhans Bettina; Gruenhage Frank; Appenrodt Beate; Nattermann Jacob; Lammert Frank; Hoerauf Achim; Sauerbruch Tilman; Stras**urg Christian P; Spengler Ulrich; Nischalke Hans Dieter

来源：Digestive and Liver Disease, 2014, 46(11): 1047-1050.

DOI：10.1016/j.dld.2014.07.008

• Ascites
• Farnesoid X receptor
• Liver cirrhosis
• Spontaneous bacterial peritonitis

Background: In mice, the farnesoid X receptor is involved in bacterial translocation, which can result in spontaneous bacterial peritonitis in patients with cirrhosis. We investigated if polymorphisms in the farnesoid X receptor gene influence the risk for spontaneous bacterial peritonitis. %26lt;br%26gt;Methods: Laboratory and clinical data of 293 cirrhotic patients with ascites and 226 healthy controls were prospectively collected. The rs56163822, rs11110390 and rs12313471 polymorphisms of the farnesoid X receptor were determined. %26lt;br%26gt;Results: 115 (39%) patients had spontaneous bacterial peritonitis. Distribution of all farnesoid X receptor genotypes matched the Hardy-Weinberg equilibrium. Patients with spontaneous bacterial peritonitis had a higher frequency of the rs56163822 GT genotype (7.0%) than patients without (1.7%, OR = 4.4, p = 0.02). This genotype was confirmed as predictor of spontaneous bacterial peritonitis by binary logistic regression analysis (OR = 6.8, p = 0.018). %26lt;br%26gt;Conclusion: The farnesoid X receptor rs56163822 GT genotype increases the risk for spontaneous bacterial peritonitis in cirrhotic patients with ascites.

• 出版日期2014-11
• 单位河北医科大学