Design and rapid fabrication of a microfluidic fraction collector

作者：Yang B^*; Lopez GC; Rosenbloom AJ; Lin Q

来源：International Journal of Nonlinear Sciences and Numerical Simulation, 2002, 3(3-4): 267-272.

• fraction collector
• hydrophobic surface
• laser engraving
• microfluidics
• surface tension

This paper presents a novel microfluidic fraction collector that directs a liquid to fill a set of collection chambers in a predetermined sequence. All microfluidic channels and liquid chambers are fabricated on a flat PDMS sheet. The device exploits surface tension effects at the microscale and uses no moving parts. The filling process can be completed with low driving pressures, estimated to be 1.33 kPa for a constant flow rate of 1 mul/min. Cross-diffusion between the individual collection chambers during the filling process is also estimated for various device geometries using typical parameters, and is shown to be generally negligible.

• 出版日期2002