Advanced Magnetic Resonance Imaging of the Physical Processes in Human Glioblastoma

作者：Kalpathy Cranner Jayashree^*; Gerstner Elizabeth R; Emblen Kyrre E; Andronesi Ovidiu C; Rosen Bruce

来源：Cancer Research, 2014, 74(17): 4622-4637.

DOI：10.1158/0008-5472.CAN-14-0383

The most common malignant primary brain tumor, glioblastorna multiforme (GBM) is a devastating disease with a grim prognosis. Patient survival is typically less than two years and fewer than 10% of patients survive more than five years. Magnetic resonance imaging (MRI) can have great utility in the diagmosis, grading, and management of patients with GBM as many of the physical manifestations of the pathologic processes in GBM can be visualized and quantified using MRI. Newer MRI techniques such as dynamic contrast enhanced and dynamic susceptibility contrast MRI provide functional information about the tumor hemodynarnic status. Diffusion MRI can shed light on tumor cellularity and the disruption of white matter tracts in the proximity of tumors. MR spectroscopy can be used to study new tumor tissue markers such as IDII mutations. MRI is helping to noninvasively explore the link between the molecular basis of gliornas and the imaging characteristics of their physical processes. We, here, review several approaches to MR-based imaging and discuss the potential for these techniques to quantify the physical processes in glioblas Loma, including tumor cellularity and vascularity, metabolite expression, and pat terns of tumor growth and recurrence. We conclude with challenges and opportunities for further research in applying physical principles to better understand the biologic process in this deadly disease.

• 出版日期2014-9-1