科研之友
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摘要
Background: In a previous study, exhaled carbon monoxide (eCO) has been assessed in healthy non-smokers with a photo acoustic spectrometer Bruel%26Kjaer 1312. Unexpectedly, values were higher than those reported in literature, which were mostly obtained with electrochemical analysers. This study was aimed to compare eCO values obtained with Bruel%26Kjaer 1312 and PiCO + Smokerlyzer, a largely utilized electrochemical analyser. %26lt;br%26gt;Methods: Thirty-four healthy subjects, 15 non- smokers and 19 smokers, underwent eCO assessment with Bruel%26Kjaer1312 and PiCO + Smokerlyzer during a prolonged expiration (15 seconds). Bruel%26Kjaer 1312 assessed CO concentration 7 and 12 seconds after the beginning of expiration and displayed the mean value. PiCO + Smokerlyzer was utilized according to the manufacturer%26apos;s recommendations. In vitro, the two devices were tested with standard concentrations of CO in nitrogen (5, 9.9, 20, and 50 ppm), and the time needed by PiCO + Smokerlyzer readings to stabilize was assessed at different gas flows. %26lt;br%26gt;Results: Both Bruel%26Kjaer 1312 and PiCO + Smokerlyzer presented very good internal consistency. The values provided were strictly correlated, but at low test concentrations, the Bruel%26Kjaer 1312 readings were greater than the PiCO + Smokerlyzer, and vice versa. PiCO + Smokerlyzer overestimated the CO standard concentrations at 5 and 9.9 ppm by 20%, while Bruel%26Kjaer 1312 measures were correct. PiCO + Smokerlyzer readings stabilized in 12 seconds during in vitro tests and in 15 seconds during in vivo measurements, suggesting that the values displayed corresponded to the initial phase of expiration. %26lt;br%26gt;Conclusions: Differences between Bruel%26Kjaer 1312 and PiCO + Smokerlyzer may be explained because Bruel%26Kjaer 1312 measured CO levels in the middle and at the end of expiration while PiCO + Smokerlyzer assessed them in the initial part of expiration.
- 出版日期2014-12-16
