A domino knoevenagel-phospha-michael reaction: One-pot synthesis of novel organophosphonates in the presence of multi-walled carbon nanotubeCONH(CH2)(2)NH-SO3H as catalyst

作者：Homayoun Fatemeh; Ghassamipour Soheila^*

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2018, 193(7): 475-480.

DOI：10.1080/10426507.2018.1452230

• Domino Knoevenagel-phospha-Michael reaction
• organophosphonates
• triethylphosphite
• 3,3-dimethyl barbituric acid
• multi-walled carbon nanotubeCONH(CH2)(2)NH-SO3H
• heterogeneous catalyst

We report a one-pot method for the synthesis of various substituted 1,3-dimethyl-2,4,6-trioxohexahydropyrimidin-5-yl phosphonate derivatives via phosphorus-carbon bond formation through domino Knoevenagel-phospha-Michael reaction. Multi-walled carbon nanotubeCONH(CH2)(2)NH-SO3H was used as an acidic heterogeneous catalyst. The catalyst could be used four times without losing its catalytic activity. The structures of the products were determined by FT-IR spectra, H-1-, C-13- and P-31- Nuclear Magnetic Resonance and elemental analysis. Recovery and reusability of catalyst, simplicity, applicability, good reaction time and good yields of products are the benefits of this work.
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• 出版日期2018