Associations of antibiotic use with risk of primary liver cancer in the Clinical Practice Research Datalink

作者：Yang Baiyu^*; Hagberg Katrina Wilcox; Chen Jie; Sahasrabuddhe Vikrant V; Graubard Barry I; Jick Susan; McGlynn Katherine A

来源：British Journal of Cancer, 2016, 115(1): 85-89.

DOI：10.1038/bjc.2016.148

• antibiotics
• liver cancer
• medical records database
• case-control study

Background: Use of antibiotics could alter human microbiota composition and decrease bacterial diversity. Such microbial dysbiosis may have implications in hepatocarcinogenesis; however, the association between antibiotic use and liver cancer risk has been minimally examined in humans.
Methods: We performed a nested case-control study (1195 primary liver cancer cases and 4640 matched controls) within the United Kingdom's Clinical Practice Research Datalink. Antibiotic use was obtained from prescription records. Multivariableadjusted odds ratio (OR) and 95% confidence interval (CI) were estimated using conditional logistic regression.
Results: Ever-use of prescription antibiotics was associated with a slightly increased risk of liver cancer, compared to non-use (OR = 1.22, 95% CI = 1.03 = 1.45). However, there was no clear dose-response relationship by the number of prescriptions or cumulative dose of antibiotic use, suggesting a non-causal association.
Conclusions: Our results do not support a role of antibiotic use in liver cancer development.

• 出版日期2016-6-28