A mathematical analysis of drug dissolution in the USP flow through apparatus

作者：McDonnell David^*; D'Arcy D. M.; Crane L. J.; Redmond Brendan

来源：Heat and Mass Transfer, 2018, 54(3): 793-801.

DOI：10.1007/s00231-017-2151-z

This paper applies boundary layer theory to the process of drug dissolution in the USP (United States Pharmacopeia) Flow Through Apparatus. The mass transfer rate from the vertical planar surface of a compact within the device is examined. The theoretical results obtained are then compared with those of experiment. The paper also examines the effect on the dissolution process caused by the interaction between natural and forced convection within the apparatus and the introduction of additional boundaries.

• 出版日期2018-3