Long-term outcomes of laparoscopic cholecystectomy: a prospective piecewise linear regression analysis

作者：Shi Hon Yi; Lee Hao Hsien; Tsai Meng Han; Chiu Chong Chi; Uen Yih Huei; Lee King Teh^*

来源：Surgical Endoscopy and Other Interventional Techniques, 2011, 25(7): 2132-2140.

DOI：10.1007/s00464-010-1508-x

• Gastrointestinal Quality-of-Life Index (GIQLI)
• Health-related quality of life
• Laparoscopic cholecystectomy
• Short-Form 36-Item Health Survey (SF-36)

Background The objectives of this study were to examine longitudinal time trends, to predict thresholds of improvement in each dimension of health-related quality of life (HRQoL), and to identify long-term predictors of HRQoL.
Methods This study analyzed 353 laparoscopic cholecystectomy (LC) patients. Disease-specific Gastrointestinal Quality-of-Life Index (GIQLI) and generic Short-Form 36-Item Health Survey (SF-36) scores were obtained immediately before surgery, then 3, 6, 12, and 24 months after surgery. Generalized estimating equations and piecewise linear regression models were used.
Results The examined population significantly (p < 0.05) improved in both SF-36 and GIQLI subscale scores. The HRQoL dimensions were substantially improved the sixth month after surgery and continued improving until they reached a plateau at 54.93 to 73.18 months. The data also showed the following explanatory variables for HRQoL: time, age, gender, Charlson Comorbidity Index, and preoperative GIQLI and SF-36 subscale scores.
Conclusions As shown by the findings, the HRQoL scores improved substantially by the sixth month after surgery and continued improving until they reached a 4- to 7-year threshold, indicating that change trends in HRQoL dimensions may vary. Although HRQoL scores were substantially improved after cholecystectomy, the improvements were associated with preoperative functional status and demographic characteristics.

• 出版日期2011-7