科研之友
微信
新浪微博
Facebook
分享链接
摘要
Metal-based therapeutics are vital tools in medicine. Metal-chelating proteins can dramatically decrease drug efficacy. Dirhodium(II) tetraacetate, a potential anticancer compound, binds in vitro to 8 cysteines of the human metallothionein 1a beta-fragment. Electrospray ionization mass spectrometry shows that the final product is the Rh-2(4+) core encapsulated by the beta fragment of the metallothionein protein protein.
- 出版日期2016
