A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells

作者：Siegle Lea; Schwab Julian D; Kuehlwein Silke D; Lausser Ludwig; Tuempel Stefan; Pfister Astrid S; Kuehl Michael; Kestler Hans A

来源：PLos One, 2018, 13(3): e0195126.

DOI：10.1371/journal.pone.0195126

Aging is a complex biological process, which determines the life span of an organism. Insulin-like growth factor (IGF) and Wnt signaling pathways govern the process of aging. Both pathways share common downstream targets that allow competitive crosstalk between these branches. Of note, a shift from IGF to Wnt signaling has been observed during aging of satellite cells. Biological regulatory networks necessary to recreate aging have not yet been discovered. Here, we established a mathematical in silico model that robustly recapitulates the crosstalk between IGF and Wnt signaling. Strikingly, it predicts critical nodes following a shift from IGF to Wnt signaling. These findings indicate that this shift might cause age-related diseases.

• 出版日期2018-3-29
• 单位河北医科大学