An extract of Artemisia dracunculus L. stimulates insulin secretion from beta cells, activates AMPK and suppresses inflammation

作者：Aggarwal Sita^*; Shailendra Giri; Ribnicky David M; Burk David; Karki Namrata; Wang M S Qingxia

来源：Journal of Ethnopharmacology, 2015, 170: 98-105.

DOI：10.1016/j.jep.2015.05.003

• Botanical(s)
• Diabetes
• Pancreatic beta (beta) cells
• Islets
• Insulin secretion
• Inflammation

Ethnopharmacological relevance: Artemisia dracunculus L (Russian tarragon) is a perennial herb belonging to the family Compositae and has a history of medicinal use in humans, particularly for treatment of diabetes.
Aim of the study: In this study a defined plant extract from A. dracunculus L. (termed PMI-5011) is used to improve beta(beta) cells function and maintain beta cell number in pancreatic islets as an alternative drug approach for successful treatment of diabetes.
Materials and methods: Mouse and human pancreatic beta cells were treated with defined plant extract of A. dracunculus L. (PMI-5011) to understand the mechanism(s) that influence beta cell function and beta cell number.
Results: We found that the PMI-5011 enhances insulin release from primary beta cells, isolated mouse and human islets and it maintains beta cell number. Insulin released by PMI-5011 is associated with the activation of AMP-activated protein kinase (AMPK), and protein kinase B (PKB). Furthermore, PMI-5011 suppresses LPS/INF gamma-induced inflammation and inflammatory mediator(s) in macrophages. PMI-5011 inhibited Nitric oxide (NO) production and expression of inducible nitric oxide synthase (iNOS) at the protein level and also attenuated pro-inflammatory cytokine (IL-6) production in macrophages.
Conclusion: PMI-5011 has potential therapeutic value for diabetes treatment via increasing insulin release from beta cells and decreases capacity of macrophages to combat inflammation.

• 出版日期2015-7-21
• 单位rutgers